The Disease.

Mast cells produced in the bone marrow travel through the body in the blood, and can invade many of the organs.  Typically the first organ to be involved is the skin.  Mast cells cluster in the skin and form spots, giving rise to a condition called Urticaria Pigmentosa.  In some people these cells cause skin irritation but, Mastocytosis being the condition it is, not all those affected suffer with skin irritation.  Mast cells can also invade the lining of the gut.  Irritation of these cells by certain triggers in foods gives rise to gut pain, diarrhoea and vomiting.  At this stage the disease can be described as systemic.  Other organs which can be involved are the liver, spleen, lungs, bones and kidneys.

Sufferers of Systemic Mastocytosis can be broadly classified as 'leakers' or 'shockers'.  A 'leaker' has mast cells which usually lose their contents slowly, giving rise to chronic intermittent pain and discomfort.  A 'shocker' on the other hand is prone to massive spontaneous degranulation of mast cells, giving rise to anaphylaxis.  People who experience anaphylaxis should consult their doctors with a view to obtaining supplies of EpiPens.  These are small personal injectors containing a single dose of Adrenaline.  They can be a life saver, but great care should be taken in their use. Click here for more info from Irene Wilson.

 JULIE DAVIDSON has compiled information sheets on  "Triggers and Degranulation" and Histamine Rich Foods

Also check out Anaesthetics , MedicAlert , EpiPen