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Trigger A trigger is something that can set of a mast cell response and bring on symptoms of mastocytosis. Not all mastocytosis patients have the same triggers. What may be a problem for one person may be ok for someone else. You may have several triggers and it may take a while to work out which ones are a problem. It may be impossible to avoid all of your triggers but once you have identified them, there are things you can do or avoid to reduce symptoms and control your mastocytosis. What is Degranulation Degranulation describes the action of the mast
cell when it is activated. When the mast cell is inactivated, or intact, it
safely contains such as histamine, tryptase, and methylhistamine. Seen through
a microscope samples can show the actual degranulated mast cells. This is seen
as a round cell surrounded by what appears to be granules. Therefore the term
degranulation is used. Degranulation List *Please note this is not an exhaustive list Anything to which the individual is known to be allergic Venoms (snake, insect stings) Biological compounds released by intestinal worms, jellyfish (on contact), crayfish and lobster. Cextran (used in some IV solutions and eye drops) Compound 48/80 Iodine- containing radioactive dyes Aspirin and other non- steroidal anti-inflammatory drugs such as Naproxen and Ibuprofen. Scopolamine Papaverine Dipyridamole Thiamine Trimethaphan Narcotic containing analgesics:
Neuromuscular blocking agents: D-tubocurarine, Decamethonium, Gallamine, Metocurine, Pancuronium Sympathomimetics (isoproterenol, amphetamine, ephedrine, phenylephrine) Alcohol Polymyxin B Quinine Dextromethorphan Local anesthetics: Lidocaine, tetracacaine, procaine, methylparaben, preservatives. Food preservatives Other factors:
* Mastocytosis sufferers should be particularly careful when faced with the use of an anaesthetic prior to an operation. Your doctors should be aware of the potential problems associated with mast cell degranulation. |